Acute blood loss stimulates fibroblast growth factor 23 production
نویسندگان
چکیده
منابع مشابه
Significance of Fibroblast Growth Factor 23 in Acute Kidney Injury.
Acute kidney injury is a clinical syndrome associated with increased patient morbidity and mortality, as well as serious short-term and long-term consequences, especially in the perioperative period. Yet, patients having suffering from temporary acute kidney injury and achieving full recovery of kidney function usually complain of poor quality of life associated with loss of energy and limited ...
متن کاملHow fibroblast growth factor 23 works.
There is a discontinuum of hereditary and acquired disorders of phosphate homeostasis that are caused by either high or low circulating levels of the novel phosphaturic hormone fibroblastic growth factor 23 (FGF23). Disorders that are caused by high circulating levels of FGF23 are characterized by hypophosphatemia, decreased production of 1,25-dihydroxyvitamin D, and rickets/osteomalacia. On th...
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Introduction Angiotensin converting enzyme (ACE) activity contributes to the vascular response to injury because ACE inhibition limits neointima formation in rat carotid arteries after balloon injury. To investigate the mechanisms by which ACE may contribute to vascular smooth muscle cell (VSMC) proliferation, we studied expression ofACE in vivo after injury and in vitro after growth factor sti...
متن کاملElevated fibroblast growth factor 23 is a risk factor for kidney transplant loss and mortality.
An increased circulating level of fibroblast growth factor 23 (FGF23) is an independent risk factor for mortality, cardiovascular disease, and progression of chronic kidney disease (CKD), but its role in transplant allograft and patient survival is unknown. We tested the hypothesis that increased FGF23 is an independent risk factor for all-cause mortality and allograft loss in a prospective coh...
متن کاملMicroRNA-297a regulates vascular calcification by targeting fibroblast growth factor 23
Objective(s): Vascular calcification is one the major characteristics in patients with various types of chronic inflammatory disorders. MiRNAs have been shown to be involved in many normal biological functions as well as diseases; however, their role in vascular calcification has not received much attention. Materials and Methods: In the current study, we built a vascular calcification rat mode...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Renal Physiology
سال: 2018
ISSN: 1931-857X,1522-1466
DOI: 10.1152/ajprenal.00081.2017